Ammonia → HCID 12793266, compound

HRID 2082740Notes

Reaction equation

HRID 2082740 reaction equation
[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([O:19]CC)=O.[NH3:22]>>[O:1]=[C:2]1[NH:7][C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH3:16])=[N:5][CH:4]=[C:3]1[C:17]([NH2:22])=[O:19]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 12535800HCID 12535800, compound

Product 1

HCID 12793266HCID 12793266, compoundYield 77%

Procedure

A mixture of ethyl 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl)pyrimidine-5-carboxylate (10.0 g.) and aqueous ammonia (120 ml., d = 0.90) was heated in a sealed vessel on a steam bath for 4.5 hours. The solution was partially evaporated and then acidified to pH 3 with 6N hydrochloric acid. The collected solid was washed with water, dried, and recrystallized from N,N-dimethylformamide to give the title compound (6.93 g., 77% yield), m.p. 236°-238°.

Workup

  1. temperaturewas heated in a sealed vessel on a steam bath for 4.5 hours
  2. customThe solution was partially evaporated
  3. washThe collected solid was washed with water
  4. customdried
  5. customrecrystallized from N,N-dimethylformamide

Sources & evidence

ORD record
ord-c70b6bd6acb649b29aafd8b6e9246d04
Source dataset
uspto-grants-1978_04
Patent number
US04082751

Reaction notes

Loading…