Ammonia → HCID 12793272, compound

Participants

Reaction Steps

A mixture of ethyl 1,6-dihydro-6-oxo-2-(2-allyloxyphenyl)-pyrimidine-5-carboxylate (5.0 g.) and liquid ammonia (50 ml.) in a steel bomb was kept at 25° for 18 hours and then heated on a steam bath for 2.5 hours. The ammonia was removed. The residue was dissolved in water and the solution acidified with acetic acid. The precipitated title compound (4.4 g., 97%), m.p. 202-204° with resolodification and remelting at 275°-280° , was recrystallized from ethanol to give analytical material, m.p. 205°-207° .

Provenance & Evidence