反应详情

A mixture of 1,6-dihydro-6-oxo-2-(2-ethoxyphenyl) pyrimidine-5-carbonitrile (2.17 g., 9.0 mmole), sodium azide (0.645 g., 9.9 mmole), and ammonium chloride (0.53 g., 9.9 mmole) in dry, N,N-dimethylformamide (18 ml.) was stirred at 125° for 16 hours. The solvent was removed under reduced pressure. The residue was treated with water and the resulting slurry acidified with 1N hydrochloric acid. The mixture was filtered. The collected solid was washed with water, dried, and recrystallized from glacial acetic acid to give the title compound (1.28 g., 50% yield). An analytical sample had m.p. 289°-290° with decomposition.

1. customin dry
2. customThe solvent was removed under reduced pressure
3. additionThe residue was treated with water
4. filtrationThe mixture was filtered
5. washThe collected solid was washed with water
6. customdried
7. customrecrystallized from glacial acetic acid