Hydrochloric Acid → HCID 178489357, compound

Participants

Reaction Steps

Sodium azide (283 mg., 4.35 mmole) was added to a solution of aluminum chloride (193 mg., 1.45 mmole) in tetrahydrofuran (8 ml.). The mixture was stirred under reflux for 0.5 hours. 1,6-Dihydro-6-oxo-2-(2-methoxyphenyl)pyrimidine-5-carbonitrile (300 mg., 1.32 mmole) was then added and the mixture stirred under reflux for 24 hours. The cooled mixture was diluted with water (15 ml.) and acidified with 6N hydrochloric acid. The mixture was filtered. The collected solid was recrystallized from glacial acetic acid to give the title compound (130 mg., 36.4% yield), m.p. 282°- 283° with decomposition. Anal. Calcd. for C12H10N6O2 : C, 53.33; H, 3.73; N, 31.10. Found: C, 53.20; H, 3.74; N, 31.50.

Provenance & Evidence