Ammonium Chloride → HCID 178450114, compound

Participants

Reaction Steps

A mixture of 1,6-dihydro-6-oxo-2-(2-isobutoxyphenyl)-pyrimidine-5-carbonitrile (3.78 g., 0.014 mole), sodium azide (1.0 g., 0.0154 mole), and ammonium chloride (0.824 g., 0.0154 mole) in N,N-dimethylformamide was heated at 125° for 19 hours stirring. The solvent was removed under reduced pressure. The residue was treated with water (40 ml.). The mixture was acidified with 6N hydrochloric acid with stirring. The mixture was filtered and the collected solid recrystallized from glacial acetic acid to give the title compound (2.4 g., 55% yield), m.p. 230°-231°.

Provenance & Evidence