HCID 12793263, compound → HCID 178458537, compound

HRID 2082752Notes

Reaction equation

HRID 2082752 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[NH:17][C:16](=[O:18])[C:15]([C:19]3[NH:23][N:22]=[N:21][N:20]=3)=[CH:14][N:13]=2)C[CH2:2]1.[O:24]=[C:25]1NC(C2C=C(OC)C=CC=2OCCC)=NC=C1C#N>>[CH3:25][O:24][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:1][CH3:2])=[C:7]([C:12]2[NH:17][C:16](=[O:18])[C:15]([C:19]3[NH:23][N:22]=[N:21][N:20]=3)=[CH:14][N:13]=2)[CH:8]=1

Participants

3

Reactant 2

HCID 12793263HCID 12793263, compoundHCID 178518675HCID 178518675, compound

Product 1

HCID 178458537HCID 178458537, compound

Procedure

In a manner similar to that described for the preparation of 2-(2-cyclopropylmethoxyphenyl)-5-(5-1H-tetrazolyl)pyrimidin-4(3H)-one in Example 9, the title compound was prepared from 1,6-dihydro-6-oxo-2-(5-methoxy-2-n-propoxyphenyl)pyrimidine-5-carbonitrile. The crude product was recrystallized from 2-methoxyethanol to give analytical material (65%), m.p. 257°-260°.

Workup

  1. customThe crude product was recrystallized from 2-methoxyethanol

Sources & evidence

ORD record
ord-adeff66831d44f878be98d3612160824
Source dataset
uspto-grants-1978_04
Patent number
US04082751

Reaction notes

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