HCID 178418361, compound → HCID 178458505, compound

HRID 2082755Notes

Reaction equation

HRID 2082755 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:22][CH2:23][CH2:24][CH3:25])=[C:8]([C:10]2[NH:15][C:14](=[O:16])[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)=[CH:12][N:11]=2)[CH:9]=1)([O-])=O.[H][H]>COCCO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:22][CH2:23][CH2:24][CH3:25])=[C:8]([C:10]2[NH:15][C:14](=[O:16])[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)=[CH:12][N:11]=2)[CH:9]=1

Participants

4

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178458519HCID 178458519, compound

Product 1

HCID 178458505HCID 178458505, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

A mixture of 2-(5-nitro-2-n-propoxyphenyl)-5-(5-1H-tetrazolyl)pyrimidine-4(3H)-one (5.0 g.) and 10% paladium-on-carbon (4.0 g.) in 2-methoxyethanol (900 ml.) was shaken in an atmosphere of hydrogen at an initial pressure of 3.5 kg./cm2 for 19 hours. The mixture was filtered and the filtrate evaporated to dryness to give the title compound (3.6 g., 79%), m.p. 250°-253° (decomp). Recrystallization from 2-methoxyethanol gave analytical material, m.p. 261°-262°.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated to dryness

Sources & evidence

ORD record
ord-c6ed5b397085443ba79c40f524635e20
Source dataset
uspto-grants-1978_04
Patent number
US04082751

Reaction notes

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