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1-Iodohexane → N-n-Hexyl-N-(3-carbethoxy-5-ethyl-2-thienyl)-2-methylpropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Iodohexane | HCID 12527 | — |
| 反応物 | Ethyl 2-amino-5-ethyl-3-thenoate | HCID 78263 | — |
| 反応物 | Ethyl 5-ethyl-2-(2-methylpropanoylamino)thiophene-3-carboxylate | HCID 734585 | — |
| 生成物 | N-n-Hexyl-N-(3-carbethoxy-5-ethyl-2-thienyl)-2-methylpropanamide | HCID 53840912 | — |
反応手順
Ethyl 2-amino-5-ethyl-3-thiophenecarboxylate (Chemische Berichte 99, 94 (1966) )was converted into N-(3-carbethoxy-5-ethyl-2-thienyl)-2-methylpropanamide by the method described in Example 41. Alkylation of the unpurified product with n-hexyl iodide as described in Example 43 gave the title compound as a light yellow oil, b.p. 145°-147° C/0.25 mm. NMR showed that the material was the correct product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04082771 |
| 出典データセット | uspto-grants-1978_04 |
| ORD ID | ord-6bf5cd6a7a2e41e497b0ff131b5cd5aa |
| 出典メモ | uspto-grants-1978_04 |