HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Carbomethoxy-5-methyl-2-thienyl)-2-methylpropanamide → 2-Methyl-N-(5-methylthiophen-2-yl)propanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Carbomethoxy-5-methyl-2-thienyl)-2-methylpropanamide | HCID 23341602 | — |
| Reactant | Lithium iodide (LiI), dihydrate | HCID 23688289 | — |
| Product | 2-Methyl-N-(5-methylthiophen-2-yl)propanamide | HCID 23341628 | 54% |
Reaction Steps
The ester from Example 48 was treated with lithium iodide dihydrate as in Example 42 to give the expected decarboxylated product, N-(5-methyl-2-thienyl)-2-methylpropanamide, m.p. 96°-97° C. in 54% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082771 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-dfce6a72668b4e31b9aa246f24d740ca |
| Source note | uspto-grants-1978_04 |