Tetrahydrofuran → HCID 178456696, compound

Participants

Reaction Steps

A stirred mixture of 2.99 g. (0.01 mole) of 7-chloro-2-(1-methylhydrazino)-5-phenyl-3H-1,4-benzodiazepine (III), 3.12 ml. (0.022 mole) of triethylamine and 40 ml. of tetrahydrofuran is cooled in an ice bath and treated with a solution of phenylisocyanide dichloride (prepared as in Agew. Chem. Internat. Ed. 6, 649) in 20 ml. of tetrahydrofuran. The resulting mixture is allowed to warm slowly to room temperature and stand for about 18 hours. It is refluxed for about b 1 hour, cooled and concentrated to give 1-anilino-8-chloro-3-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepinium chloride (VIII).

Provenance & Evidence