HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2082792Generated: November 1, 2026
3,3-Dimethyl-2,5-hexanedione → 5-Hydroxy-3,3-dimethylhexan-2-one
https://huagongshe.com/reaction/2082792
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3,3-Dimethyl-2,5-hexanedione | HCID 164742 | — |
| Reactant | Lithium perhydro-9b-boraphenalylhydride | HCID 70418318 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Hydroxy-3,3-dimethylhexan-2-one | HCID 20360671 | 90% |
Reaction Steps
In a flask is placed 100 mmoles of 3,3-dimethyl-2,5-hexanedione in 50 ml. of tetrahydrofuran. The reaction mixture is cooled to 0° C. and 100 mmoles of lithium perhydro-9b-boraphenalylhydride is added slowly. A 90% yield of 3,3-dimethyl-5-hydroxy-2-hexanone is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04082810 |
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| Source dataset | uspto-grants-1978_04 |
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| ORD ID | ord-bb0063a3d7fa446099adeed3cdc06e61 |
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| Source note | uspto-grants-1978_04 |
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