Nitric Acid → HCID 18351994, compound

Participants

Reaction Conditions

Reaction Steps

3-(4-Fluorobenzoyl)propionic acid (250 g, 1.28 mole) was added in portions to stirred fuming nitric acid (1000 ml) maintained at -15° C, the mixture was stirred an additional 30 minutes and then poured into ice-water (3000 ml). The product was collected, washed with water, and recrystallised from propanol to give 3-(4-fluoro-3-nitrobenzoyl)propionic acid (175 g, 56%, m.p. 136° C). (Found: C, 49.98; H, 3.34; N, 5.69. C10H8FNO5 requires: C, 49.80; H, 3.34; N, 5.81%)

Provenance & Evidence