Cyclohexene → HCID 20360774, compound

HRID 2082817Notes

Reaction equation

HRID 2082817 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][C:3]=1[N+:15]([O-])=O.C1CCCCC=1>[Pd].C(O)C>[NH2:15][C:3]1[CH:4]=[C:5]([CH:13]=[CH:14][C:2]=1[F:1])[C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7]

Participants

5

Reactant 2

HCID 8079CyclohexeneHCID 18351994HCID 18351994, compound

Product 1

HCID 20360774HCID 20360774, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A stirred mixture of 3-(4-fluoro-3-nitrobenzoyl)propionic acid, cyclohexene, palladium on charcoal, and ethanol, was heated under reflux for 18 hours. Evaporation of the filtered solution gave 3-(3-amino-4-fluorobenzoyl)propionic acid.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 18 hours
  3. customEvaporation of the filtered solution

Sources & evidence

ORD record
ord-80daa6fbf2344ee3b9b785d4b0d5a494
Source dataset
uspto-grants-1978_04
Patent number
US04082843

Reaction notes

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