HCID 20360774, compound → HCID 20360749, compound

HRID 2082818Notes

Reaction equation

HRID 2082818 reaction equation
N[C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[F:15])[C:5]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[O:6].N([O-])=[O:17].[Na+]>S(=O)(=O)(O)O>[F:15][C:14]1[CH:13]=[CH:12][C:4]([C:5]([CH2:7][CH2:8][C:9]([OH:11])=[O:10])=[O:6])=[CH:3][C:2]=1[OH:17]

Participants

4

Reactant 2

HCID 20360774HCID 20360774, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 20360749HCID 20360749, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

3-(3-amino-4-fluorobenzoyl)propionic acid was diazotised in sulphuric acid solution with sodium nitrite and the diazonium salt solution was added dropwise to boiling aqueous sulphuric acid to give 3-(4-fluoro-3-hydroxybenzoyl)propionic acid.

Sources & evidence

ORD record
ord-5a084b69a9da49fd8553b180c0f357f6
Source dataset
uspto-grants-1978_04
Patent number
US04082843

Reaction notes

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