Cyclohexene → HCID 20360731, compound

HRID 2082825Notes

Reaction equation

HRID 2082825 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:26])[CH2:8][O:9][C:10]1[CH:11]=[C:12]([C:19]2[CH2:20][CH2:21][C:22](=[O:25])[NH:23][N:24]=2)[CH:13]=[CH:14][C:15]=1[N+:16]([O-])=O)([CH3:4])([CH3:3])[CH3:2].C1CCCCC=1>C(O)C.[Pd]>[NH2:16][C:15]1[CH:14]=[CH:13][C:12]([C:19]2[CH2:20][CH2:21][C:22](=[O:25])[NH:23][N:24]=2)=[CH:11][C:10]=1[O:9][CH2:8][CH:7]([OH:26])[CH2:6][NH:5][C:1]([CH3:3])([CH3:2])[CH3:4]

Participants

5

Reactant 2

HCID 8079CyclohexeneHCID 20360788HCID 20360788, compound

Product 1

HCID 20360731HCID 20360731, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 6-[3-(3-t-butylamino-2-hydroxypropoxy)-4-nitrophenyl]-4,5-dihydro-3(2H)-pyridazinone in ethanol was heated under reflux with palladium on charcoal and excess of cyclohexene for 18 hours. Evaporation of the filtered solution under reduced pressure gave 6-[4-amino-3-(3-t-butylamino-2-hydroxypropoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Workup

  1. customEvaporation of the filtered solution under reduced pressure

Sources & evidence

ORD record
ord-63a2469bb493483a81b242e4ac8ba14b
Source dataset
uspto-grants-1978_04
Patent number
US04082843

Reaction notes

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