Potassium Hydroxide → HCID 20360751, compound

HRID 2082829Notes

Reaction equation

HRID 2082829 reaction equation
Cl[CH2:2][C:3]1[CH:16]=[CH:15][C:6]([C:7]([CH2:9][CH2:10][C:11]([O:13]C)=[O:12])=[O:8])=[CH:5][C:4]=1[OH:17].[OH-:18].[K+]>>[OH:17][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:3]=1[CH2:2][OH:18])[C:7]([CH2:9][CH2:10][C:11]([OH:13])=[O:12])=[O:8]

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 20360760HCID 20360760, compound

Product 1

HCID 20360751HCID 20360751, compound

Procedure

A mixture of methyl 3-(4-chloromethyl-3-hydroxybenzoyl)-propionate and 3N potassium hydroxide solution was heated under reflux for 4 hours to give 3-(3-hydroxy-4-hydroxymethylbenzoyl)propionic acid.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours

Sources & evidence

ORD record
ord-bf2f292a8d034e85812b901b47ba2849
Source dataset
uspto-grants-1978_04
Patent number
US04082843

Reaction notes

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