Sodium Methoxide → HCID 135840394, compound

HRID 2082832Notes

Reaction equation

HRID 2082832 reaction equation
[OH:1][C:2]1[C:7]([OH:8])=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=1.Cl[CH2:17][CH:18]1[O:22][CH:21]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:20]([CH:29]([CH3:31])[CH3:30])[CH2:19]1.C[O-].[Na+]>>[OH:1][C:2]1[C:7]([O:8][CH2:17][CH:18]2[O:22][CH:21]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=3)[N:20]([CH:29]([CH3:31])[CH3:30])[CH2:19]2)=[CH:6][CH:5]=[CH:4][C:3]=1[C:9]1[CH2:10][CH2:11][C:12](=[O:15])[NH:13][N:14]=1

Participants

4

Reactant 3

HCID 10942334Sodium MethoxideHCID 20557049HCID 20557049, compoundHCID 135840395HCID 135840395, compound

Product 1

HCID 135840394HCID 135840394, compound

Procedure

6-(2,3-Dihydroxyphenyl)-4,5-dihydro-3(2H)-pyridazinone was reacted with 5-chloromethyl-3-isopropyl-2-phenyloxazolidine in the presence of sodium methoxide to give 6-[2-hydroxy-3-(3-isopropyl-2-phenyl-5-oxazolidinylmethoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-8021f9d1717649e6a4425f2cfb5ba214
Source dataset
uspto-grants-1978_04
Patent number
US04082843

Reaction notes

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