Water → HCID 20360757, compound

Participants

Reaction Conditions

Reaction Steps

A solution of redistilled acrylonitrile (20 g, 0.375 mole) in dimethylformamide (100 ml) was added dropwise to a stirred solution of 3-acetoxy-2-chlorobenzaldehyde (99.2 g, 0.5 mole) and sodium cyanide (12.25 g, 0.25 mole) in dimethylformamide (250 ml) at 35° C during 30 minutes. The mixture was stirred at 35° C for 4 hours, then poured into twice its own volume of water and the mixture was extracted with chloroform. The washed and dried extract was evaporated to give 3-(3-acetoxy-2-chlorobenzoyl)propionitrile.

Provenance & Evidence