Potassium Hydroxide → HCID 12330019, compound

HRID 2082857Notes

Reaction equation

C([O:3][C:4]([C:6]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:7]=1[CH2:8][O:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][C:17]([O:19]CC)=[O:18])=[CH:12][CH:11]=1)=[O:5])C.[OH-].[K+]>>[C:4]([C:6]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:7]=1[CH2:8][O:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:16][C:17]([OH:19])=[O:18])=[CH:14][CH:15]=1)([OH:5])=[O:3]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 21269162HCID 21269162, compound

Product 1

HCID 12330019HCID 12330019, compound

Procedure

Reaction of ethyl 4-(2-ethoxycarbonyl-4-fluorobenzyloxy)phenylacetate with potassium hydroxide as described in Example 1c provides colorless crystals, mp 195°-197° C of 4-(2-carboxy-4-fluorobenzyloxy)phenylacetic acid.

Sources & evidence

ORD record: ord-bdab8fc4e7be43c1ba58d7faa7c6115e
Source dataset: uspto-grants-1978_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04082850

Reaction notes

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