Potassium Hydroxide → HCID 12330022, compound

HRID 2082859Notes

Reaction equation

[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([O:24]CC)=[O:23])[C:3]=1[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([O:15]CC)=[O:14])=[CH:8][CH:7]=1.[OH-].[K+]>>[C:22]([C:18]1[C:3]([CH2:4][O:5][C:6]2[CH:11]=[CH:10][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[CH:8][CH:7]=2)=[C:2]([Cl:1])[CH:21]=[CH:20][CH:19]=1)([OH:24])=[O:23]

Participants

Reactant 2

HCID 14797Potassium Hydroxide

HCID 21269134Ethyl 4-[[2-chloro-6-(ethoxycarbonyl)phenyl]methoxy]benzeneacetate

Product 1

HCID 12330022HCID 12330022, compound

Procedure

Reaction of ethyl 4-(2-chloro-6-ethoxycarbonylbenzyloxy)phenylacetate with potassium hydroxide as described in Example 1c provides 4-(6-carboxy-2-chlorobenzyloxy)phenylacetic acid as a colorless solid, mp 171°-173° C.

Sources & evidence

ORD record: ord-34eceeb3c7484e92ac89d094e01191b6
Source dataset: uspto-grants-1978_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04082850

Reaction notes

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