HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → 5-(Hydroxymethyl)-3-(methylamino)-2-phenoxybenzene-1-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-Amino-5-(hydroxymethyl)-2-phenoxybenzene-1-sulfonamide | HCID 54036191 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-(Hydroxymethyl)-3-(methylamino)-2-phenoxybenzene-1-sulfonamide | HCID 54137754 | — |
Reaction Steps
A mixture of 3-amino-4-phenoxy-5-sulfamylbenzyl alcohol (8.8 g; prepared as described in Example 2), methyl iodide (2.1 ml), sodium hydrogen carbonate (5.0 g) and hexamethylphosphoric triamide (45 ml) is stirred at 22°-25° C for 18 hours. The mixture is then diluted with water (about 500 ml) to precipitate crude 3-methylamino-4-phenoxy-5-sulfamylbenzyl alcohol. After recrystallization from aqueous ethanol it is obtained with a melting point of 167°-168° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082851 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-e7e2cdf2c8b344fa87c6cab8d30fa442 |
| Source note | uspto-grants-1978_04 |