HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 3-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 3-Amino-2-benzyl-5-(hydroxymethyl)benzene-1-sulfonamide | HCID 53686929 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide | HCID 20294537 | — |
Reaction Steps
3-Amino-4-benzyl-5-sulfamylbenzyl alcohol (12.5 g; prepared as described in Example 4) is while stirring added in portions to acetic acid saturated with dry hydrogen bromide (60 ml), and the mixture is stirred for 24 hours. The resulting solution is diluted with diethyl ether (150 ml) and cooled to precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082851 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-1d863e0d0f6b49e69c8cf574965082b2 |
| Source note | uspto-grants-1978_04 |