4-benzyl-3-n-butoxy-5-sulfamyl-N-(3'-piperidinopropyl)benzamide → (4-Benzyl-3-n-butoxy-5-sulfamylbenzyl)-3-piperidinopropylamine

HRID 2082886Notes

Reaction equation

HRID 2082886 reaction equation
C(NC1C=C(C=C(S(=O)(=O)N)C=1OC1C=CC=CC=1)C(N)=O)CCC.[CH2:26]([C:33]1[C:50]([S:51](=[O:54])(=[O:53])[NH2:52])=[CH:49][C:36]([C:37]([NH:39][CH2:40][CH2:41][CH2:42][N:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)=O)=[CH:35][C:34]=1[O:55][CH2:56][CH2:57][CH2:58][CH3:59])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[CH2:26]([C:33]1[C:50]([S:51](=[O:54])(=[O:53])[NH2:52])=[CH:49][C:36]([CH2:37][NH:39][CH2:40][CH2:41][CH2:42][N:43]2[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48]2)=[CH:35][C:34]=1[O:55][CH2:56][CH2:57][CH2:58][CH3:59])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 202945614-benzyl-3-n-butoxy-5-sulfamyl-N-(3'-piperidinopropyl)benzamideHCID 215060653-Butylamino-4-phenoxy-5-sulphamyl-benzamide

Product 1

HCID 54179160(4-Benzyl-3-n-butoxy-5-sulfamylbenzyl)-3-piperidinopropylamine

Procedure

By replacing in Example 289 3-n-butylamino-4-phenoxy-5-sulfamylbenzamide with an equimolar amount of 4-benzyl-3-n-butoxy-5-sulfamyl-N-(3'-piperidinopropyl)benzamide and following the procedure described, (4-benzyl-3-n-butoxy-5-sulfamylbenzyl)-3-piperidinopropylamine is obtained as a hemihydrate with a melting point of 98°-101° C.

Sources & evidence

ORD record
ord-04058763ac5b477988334716000f6303
Source dataset
uspto-grants-1978_04
Patent number
US04082851

Reaction notes

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