Phosphorus oxychloride → 3-(Butylamino)-5-cyano-2-phenoxybenzene-1-sulfonamide

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-n-butylamino-4-phenoxy-5-sulfamylbenzamide (8.5g) and phosphorus oxychloride (25 ml) is heated at 120° C. for 2 hours. The mixture is then evaporated in vacuo and the residue is triturated with icewater (120 ml) to yield crude 3-n-butylamino-4-phenoxy5-sulfamylbenzonitrile. After filtration, carefully washing with water, drying and recrystallization from methanol, it is obtained with a melting point of 217°-218° C.

Provenance & Evidence