HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-benzyl-N-(3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | (3-n-Butylamino-4-phenoxy-5-sulfamylbenzyl)benzylamine | HCID 53795311 | — |
| Solvent | Acetic Anhydride | HCID 7918 | — |
| Product | N-benzyl-N-(3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)acetamide | HCID 53734224 | — |
Reaction Steps
To a solution of (3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)benzylamine (1.1 g; prepared as described in Example 136) in pyridine (6 ml), acetic anhydride (0.26 ml) is added and the mixture is left for 3 hours. Water (25 ml) is then added followed by concentrated hydrochloric acid (3 ml) to precipitate a semi-solid material. After recrystallization twice from aqueous ethanol, N-benzyl-N-(3-n-butylamino-4-phenoxy-5-sulfamylbenzyl)acetamide is obtained with a melting point of 75°-77° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04082851 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-7e82cac508f749e0b0cb1cdcc027504a |
| Source note | uspto-grants-1978_04 |