Methyl 3-amino-4-benzyl-5-butoxybenzoate → (3-Amino-4-benzyl-5-butoxyphenyl)methanol

HRID 2082899Notes

Reaction equation

HRID 2082899 reaction equation
NC1C=C(C=C(S(=O)(=O)N)C=1CC1C=CC=CC=1)C(OC)=O.[NH2:23][C:24]1[C:25]([CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[C:26]([O:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH:27]=[C:28]([CH:33]=1)[C:29](OC)=[O:30]>>[NH2:23][C:24]1[C:25]([CH2:39][C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)=[C:26]([O:34][CH2:35][CH2:36][CH2:37][CH3:38])[CH:27]=[C:28]([CH:33]=1)[CH2:29][OH:30]

Participants

3

Reactant 2

HCID 20294616Methyl 3-amino-4-benzyl-5-butoxybenzoateHCID 20294631Methyl 3-amino-4-benzyl-5-sulfamoylbenzoate

Product 1

HCID 54254010(3-Amino-4-benzyl-5-butoxyphenyl)methanol

Procedure

By replacing in Example 4 methyl 3-amino-4-benzyl-5-sulfamylbenzoate with an equimolar amount of methyl 5-amino-4-benzyl-3-n-butoxybenzoate (mp 82°-83° C.) and following the procedure described, 5-amino-4-benzyl-3-n-butoxybenzyl alcohol is obtained with a melting point of 105°-107° C.

Sources & evidence

ORD record
ord-76656864db1f4b019ebc1d08fcecc04c
Source dataset
uspto-grants-1978_04
Patent number
US04082851

Reaction notes

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