Dimethylamine → (5-Amino-4-benzyl-3-n-butoxybenzyl)dimethylamine

HRID 2082900Notes

Reaction equation

Br.NC1C=C(C=C(S(=O)(=O)N)C=1CC1C=CC=CC=1)CBr.C(N)CCC.Br.[NH2:28][C:29]1[C:30]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)=[C:31]([O:37][CH2:38][CH2:39][CH2:40][CH3:41])[CH:32]=[C:33]([CH:36]=1)[CH2:34]Br.[CH3:49][NH:50][CH3:51]>>[NH2:28][C:29]1[C:30]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)=[C:31]([O:37][CH2:38][CH2:39][CH2:40][CH3:41])[CH:32]=[C:33]([CH:36]=1)[CH2:34][N:50]([CH3:51])[CH3:49]

Participants

Reactant 4

HCID 674Dimethylamine

HCID 8007Butylamine

HCID 202945373-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

HCID 705750415-Amino-4-benzyl-3-n-butoxybenzyl bromide hydrobromide

Product 1

HCID 20294557(5-Amino-4-benzyl-3-n-butoxybenzyl)dimethylamine

Procedure

By replacing in Example 110 3-amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide and n-butylamine with 5-amino-4-benzyl-3-n-butoxybenzyl bromide hydrobromide and dimethylamine (40% in water) respectively, and following the procedure described, (5-amino-4-benzyl-3-n-butoxybenzyl)dimethylamine is obtained as a semi-solid material.

Sources & evidence

ORD record: ord-2d99d40c0bbd49118d30f4400b01272a
Source dataset: uspto-grants-1978_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04082851

Reaction notes

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