HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2082912Generated: October 30, 2026
Benzoyl chloride → Benzamide, N-[5-(1-cyanoethyl)-2-hydroxyphenyl]-
https://huagongshe.com/reaction/2082912
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoyl chloride | HCID 7412 | — |
| Reactant | 2-(3-Amino-4-hydroxyphenyl)propanenitrile | HCID 12202636 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Benzamide, N-[5-(1-cyanoethyl)-2-hydroxyphenyl]- | HCID 12202639 | — |
Reaction Steps
Benzoyl chloride (27.09 g., 0.19 mole.) was added, with cooling, during 20 minutes to a stirred solution of 2-(3-amino-4-hydroxyphenyl) propionitrile (28.35 g., 0.175 mole.) in dry pyridine (200 ml.) at 0° - 3° C. After addition was complete, the mixture was heated at 100° C. for 1 hour. It was then evaporated under reduced pressure to yield crude 2-(3-benzamido-4-hydroxyphenyl) propionitrile as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | USRE029608 |
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| Source dataset | uspto-grants-1978_04 |
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| ORD ID | ord-c000933a20144145be558a1480f27a13 |
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| Source note | uspto-grants-1978_04 |
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