3-Cyanopyridine → HCID 12257652, compound

Participants

Reaction Steps

Sodium (0.115 g.) was dissolved carefully in methanol (45 ml.) and 3-cyanopyridine (5.2 g.) was added. Next day, acetic acid (0.3 g.) was added followed by 2-(3-amino-4-hydroxyphenyl)propionic acid (9.05 g.). The stirred mixture was heated under reflux for 5 hours. The solid dissolved completely during this time. An equal volume of water was added to the hot solution. On cooling, cream crystals separated which were filtered off and re-crystallized from dimethylformamide-ethanol to yield the desired acid, m.p. 197° - 200° C.

Provenance & Evidence