HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 2-(3-acetamido-4-hydroxyphenyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl 3-amino-4-hydroxy-phenyl-propionate | HCID 12202638 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Ethyl 2-(3-acetamido-4-hydroxyphenyl)propionate | HCID 20358686 | 65.7% |
Reaction Steps
A solution of ethyl 2-(3-amino-4-hydroxyphenyl)-propionate (10.46 g.) and acetic anhydride (5.6 g.) in dry pyridine (50 ml.) was heated on a steam bath for 1.25 hours. The reaction mixture was poured into water (500 ml.), precipitating an oil. On cooling the oil solidified. The solid was removed by filtration and washed with water. After drying, ethyl 2-(3-acetamido-4-hydroxyphenyl)propionate (8.25 g.) was obtained, m.p. 137° - 141° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE029608 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-17dc4aa3be6f4a5f97f35debf907981e |
| Source note | uspto-grants-1978_04 |