Ammonia → 6-Methyl-2,4-pyrimidinediamine

Participants

Reaction Steps

2,4-Diamino-6-methyl pyrimidine was prepared by a modified procedure of Gabriel and Coleman (Ber., volume 34, page 1253, 1901). A mixture of 2-amino-4-chloro-6-methyl pyrimidine (9.0 gm) and alcoholic ammonia (225 ml), were heated in a steel bomb at 180° C for 6 hours. The mixture was then filtered, and the filtrate was evaporated to dryness. The solid residue was dissolved in 60ml hot water. The solution was cooled to room temperature, and 40 gm of potassium hydroxide was then added. The product thus precipitated, was filtered, and crystallized from acetone, m.p. 183° C. Yield: 5.5gm. U.V. spectrum data corresponded to those reported by Curd and Rose (J.C.S., page 98, 1949).

Provenance & Evidence