Ammonia → HCID 178429547, compound

Participants

Reaction Steps

92 Parts of an 18.5 percent strength by weight aqueous solution of ammonia are added to 122.5 parts of ethyl chloroacetate at from 10° to 15° C. After stirring for 2 hours, 200 parts of dimethylformamide and 167 parts of a 29.4 percent strength by weight solution of sodium cyanide in water are added. The reaction mixture is kept for 3 hours at 40° C, and 130 parts of ethyl acetoacetate are then added, followed by 139 parts of an 18.5 percent strength by weight aqueous ammonia solution. The mixtue is kept for 4 hours at 90° to 95° C. It is then worked up as described in Example 1. 10.2 parts of 2-hydroxy-5-cyano-4-methylpyrid-6-one (68% of theory, based on ethyl chloroacetate employed) of melting point 298°-302° C (with decomposition) are obtained.

Provenance & Evidence