Ammonia → HCID 178448683, compound

Participants

Reaction Conditions

Reaction Steps

73 Parts of n-butylamine are added to 109 l parts of methyl chloroacetate at from 10° to 15° C. The reaction mixture is stirred for a further 2 hours at 15° C and 125 parts of dimethylformamide and 167 parts of a 30 percent strength by weight aqueous sodium cyanide solution are then added. The mixture is stirred for 5 hours at 40° C. After adding 116 l parts of methyl acetoacetate and 123 parts of a 21 percent strength by weight aqueous ammonia solution, the mixture is stirred for 4 hours at 90° C and is worked up as described in Example 1. 120 parts of 1-butyl-2-hydroxy-5-cyano-4-methylpyrid-6-one (58% of theory, based on methyl chloroacetate) of melting point 218°-222° C are obtained.

Provenance & Evidence