Boron trifluoride etherate → HCID 178526262, compound

Participants

Reaction Steps

A solution of 40.5 g (0.12 mole) 2,4'-dichloro-2'-(4-hydroxybenzoyl)-acetanilide oxime and 40.5 mg (0.329 mole) of boron trifluoride etherate was heated to reflux. After 5 hr, it was cooled and 200 ml of water was added. The dioxane was removed by distillation and the reaction mixture was made basic with a 5% sodium bicarbonate solution. The solid was collected, heated in methanol at reflux for a few minutes, cooled and collected to give, in two crops, 21.3 g (56%) of product. An analytical sample which was recrystallized from methanol melted at 226°-227° dec.

Provenance & Evidence