Methylamine → HCID 178482319, compound

Participants

Reaction Steps

To a saturated solution of methylamine in 600 ml of methanol in an ice bath was added 19.2 g (0.60 mole) of 6-chloro-2-chloromethyl-4-(4-hydroxyphenyl) quinazoline 3-oxide. The solution was stirred for 7 hr in an ice bath, and 10 hr at room temperature and then evaporated under reduced pressure. The residue was acidified with dilute acetic acid, stirred with ether and filtered to give 19 g of product. Recrystallization for analysis from ethyl acetate gave colorless plates, mp 278°-279° dec.

Provenance & Evidence