Bromoacetyl bromide → HCID 12517307, compound

Participants

Reaction Steps

To a stirred mixture of 56 g (0.163 mole) of 2-amino-5-chloro-4'-(2,2,2-trifluoroacetamido)-benzophenone in 900 ml of ether was added 43 g (0.213 mole) of bromoacetyl bromide and a saturated aqueous solution of sodium bicarbonate in portions, keeping the solution slightly basis during the addition. The reaction was stirred for 90 min and filtered to give 66 g of product. The ether layer was dried and evaporated and the residual oil was crystallized from methanol to give an additional 10 g of the product for a total yield of 76 g (96%). Recrystallization from a mixture of dichloromethane, methanol and petroleum ether gave an analytical sample of off white rods, mp 198°-201° ir (KBr) 1750, 1663, 1640 cm-1 (3C=O).

Provenance & Evidence