Acetic Acid → HCID 86735614, compound

Participants

Reaction Conditions

Reaction Steps

To a solution prepared from 3 g sodium metal in 100 ml absolute methanol there was added 45 g methyl benzyl ketone. The resulting solution was refluxed for 30 minutes, cooled to 0° C and 39 g 2-methylene-3-quinuclidinone was added. The solution was stirred at ambient temperature during 48 hours, neutralized by the addition of 3 ml acetic acid and the solvents were removed under reduced pressure. There was obtained a crude oil which was extracted with chloroform. After evaporation of the solvent there was obtained 52 g (a yield of 60% ) of the desired product, M.P. from acetone, 125.7° C. Treatment with hydrochloric acid gave the corresponding hydrochloride salt, M.P. above 300° C (dec.).

Provenance & Evidence