N,N'-Dimethylthiourea → HCID 20359073, compound

HRID 2083028Notes

Reaction equation

HRID 2083028 reaction equation
[C:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([C:15](=[O:18])[CH2:16][Br:17])[CH:11]=[CH:12][C:13]=1[Cl:14])(=[O:7])=[O:6])(=[O:3])[CH3:2].[CH3:19][NH:20][C:21]([NH:23][CH3:24])=[S:22]>C(O)C.CC(C)=O>[BrH:17].[C:1]([NH:4][S:5]([C:8]1[CH:9]=[C:10]([C:15]2([OH:18])[CH2:16][S:22][C:21](=[N:20][CH3:19])[N:23]2[CH3:24])[CH:11]=[CH:12][C:13]=1[Cl:14])(=[O:7])=[O:6])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 2723631N,N'-DimethylthioureaHCID 20359072HCID 20359072, compound

Product 1

HCID 20359073HCID 20359073, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 702EthanolSolvent

Procedure

10.5 g of 3'-acetylsulfamoyl-2-bromo-4'-chloro-acetophenone are dissolved in 100 ml of ethanol and heated to 45°-50° C during 5 minutes after the addition of 3 g of 1,3-dimethyl thiourea. After standing overnight at 20° C the solvent is expelled under reduced pressure, the residue is dissolved in acetone and the product is precipitated with diisopropyl ether while stirring.

Workup

  1. temperatureheated to 45°-50° C during 5 minutes
  2. customthe product is precipitated with diisopropyl ether

Sources & evidence

ORD record
ord-e6c07cc21ec547bd8a7906e919817f57
Source dataset
uspto-grants-1978_04
Patent number
US04083979

Reaction notes

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