HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3,4-dichlorobenzenesulphonyl)-N', S-dimethylisothiourea → N-(3,4-dichlorobenzenesulphonyl)-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3,4-dichlorobenzenesulphonyl)-N', S-dimethylisothiourea | HCID 22756464 | — |
| Reactant | HCID 178433288 | HCID 178433288 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(3,4-dichlorobenzenesulphonyl)-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine | HCID 178485014 | — |
Reaction Steps
A solution of 4-methyl-5-((2-aminoethyl)thiomethyl)imidazole (3.49 g.) and N-(3.4-dichlorobenzenesulphonyl)-N', S-dimethylisothiourea (6.20 g.) in acetonitrile (250 ml.) was heated under reflux for 48 hours. Concentration, followed by chromatographic purification on a column of alumina with sequential elution by benzene-ethylacetate (1:4) and benzene-ethanol (1:4) afforded N-(3,4-dichlorobenzenesulphonyl)-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl] guanidine as a glass (1.7 g.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04083988 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-af23be71b41f447ca4ba977abdbed593 |
| Source note | uspto-grants-1978_04 |