HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(Chloromethyl)-4-methoxypyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (4-Methoxy-pyridin-2-yl)-methanol | HCID 10820596 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(Chloromethyl)-4-methoxypyridine hydrochloride | HCID 13923368 | — |
Reaction Steps
Thionyl chloride (23 cc) was added over 25 minutes to a stirred solution of 2-hydroxymethyl-4-methoxypyridine (8.935 g) in chloroform at room temperature, and the mixture was stirred for a further 2 hours and was evaporated to dryness and the residue was triturated with ether and recrystallised from 0.9N ethanolic hydrogen chloride/ether (7:5) to give 2-chloromethyl-4-methoxypyridine hydrochloride m.p. 142° (decomp).(12.1 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04083983 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-322dc093698c40919ac9bd30ac81d339 |
| Source note | uspto-grants-1978_04 |