HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → 2-Chloro-7-(trifluoromethyl)quinoxaline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 6-(Trifluoromethyl)quinoxalin-2(1H)-one | HCID 12686390 | — |
| Reactant | 7-(Trifluoromethyl)quinoxalin-2(1H)-one | HCID 15893375 | — |
| Product | 2-Chloro-7-(trifluoromethyl)quinoxaline | HCID 21313161 | — |
Reaction Steps
This 7-trifluoromethylquinoxalin-2-one was allowed to react with phosphorus oxychloride (in the same manner as described above for 6-trifluoromethylquinoxalin-2-one) to yield the intermediate 2-chloro-7-trifluoromethylquinoxaline having a melting point of about 119°-120° C. This compound was allowed to react with ammonia, in the manner described above, to yield the 2-amino-7-trifluoromethylquinoxaline, having a melting point of about 192°-194° C., and identified by IR spectrum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04083977 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-f8d8ab15b089471d834ba12486450736 |
| Source note | uspto-grants-1978_04 |