HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminopentan-1-ol → N-cyano-N'-(5-hydroxypentyl)-N"-methylguanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminopentan-1-ol | HCID 75634 | — |
| Reactant | 1-Cyano-2,3-dimethylisothiourea | HCID 111103 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-cyano-N'-(5-hydroxypentyl)-N"-methylguanidine | HCID 54552768 | 44% |
Reaction Steps
A mixture of 5-aminopentan-1-ol (20 g.) and N-cyano-N',S-dimethylisothiourea (25 g.) in pyridine (130 ml) was heated on a steam-bath for 14 hours, evaporated to dryness, and the residue recrystallised from chloroform/methanol to give N-cyano-N'-(5-hydroxypentyl)-N"-methylguanidine (15.7 g). A recrystallised sample had m.p. 116°-119°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04084001 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-0c29a52548724e7cb11a16f2ff51a744 |
| Source note | uspto-grants-1978_04 |