Carbon Dioxide → Phenylacetic Acid

Participants

Reaction Conditions

Reaction Steps

In accordance with the process of Example 1, 12.7 g of chlorotoluene (a mixture of 67.03% of o-chlorotoluene and 32.97% of p-chlorotoluene) produced by reacting toluene with chlorine in carbon tetrachloride was mixed with 5.4 g of sodium dispersed in 50 ml of 1.4-dioxane. The reaction mixture was heated at 100° C for 3 hours to rearrange the product. The reaction mixture was cooled to 25° C to 28° C and carbon dioxide gas was introduced into the reaction mixture to effect carboxylation with the rearranged product. After the reaction, the post-treatment was carried out in accordance with the process of Example 1 whereby 13.1 g of phenylacetic acid (yield 96.3%) were obtained.

Provenance & Evidence