HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic anhydride → Pga1
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic anhydride | HCID 9845 | — |
| Reactant | Alprostadil | HCID 5280723 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Pga1 | HCID 5281912 | — |
Reaction Steps
Alternately, the PGE1 -type compound is transformed to a bis-trifluoroacetate, for example by reaction with trifluoroacetic anhydride in the presence of pyridine in a solvent at 0° to 5° C., and thereafter contacted with a low-boiling alcohol (preferably b.p. below 110° C.) with a tertiary amine to form a PGA1 -type compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04084058 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-a8e7c762ebe24d738a60e50612ac1932 |
| Source note | uspto-grants-1978_04 |