HCID 70594148, compound → HCID 70590259, compound

HRID 2083151Notes

Reaction equation

HRID 2083151 reaction equation
Br[CH2:2][C:3]1([CH3:28])[CH:7]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[N:6]2[C:16](=[O:27])[CH:17]([NH:18][C:19](=[O:26])[CH2:20][N:21]3[CH:25]=[N:24][N:23]=[N:22]3)[C@H:5]2[S:4]1.[CH3:29][N:30]1[C:34]([SH:35])=[N:33][N:32]=[N:31]1>P([O-])([O-])([O-])=O.CC(C)=O>[CH3:29][N:30]1[C:34]([S:35][CH2:2][C:3]2([CH3:28])[CH:7]([C:8]([O:10][CH2:11][C:12]([Cl:15])([Cl:14])[Cl:13])=[O:9])[N:6]3[C:16](=[O:27])[CH:17]([NH:18][C:19](=[O:26])[CH2:20][N:21]4[CH:25]=[N:24][N:23]=[N:22]4)[C@H:5]3[S:4]2)=[N:33][N:32]=[N:31]1

Participants

5

Reactant 2

HCID 70594148HCID 70594148, compoundHCID 178482017HCID 178482017, compound

Product 1

HCID 70590259HCID 70590259, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 1061PhosphateSolvent

Procedure

By treating in the similar manner as described in Example 11 using 2,2,2-trichloroethyl 2-bromomethyl-2-methyl-6-[2-(1H-tetrazol-1-yl)-acetamido]penam-3-carboxylate and 1-methyl-1H-tetrazole-5-thiol in a mixture of pH 6.85 phosphate buffer and acetone, there was obtained amorphous 2,2,2-trichloroethyl 2-(1-methyl-1H-tetrazol-5-yl)thiomethyl-2-methyl-6-[2-(1H-tetrazol-1-yl)acetamido]penam-3-carboxylate.

Workup

  1. additionBy treating in the similar manner

Sources & evidence

ORD record
ord-779a5dc7f22541a6813d240bc318997c
Source dataset
uspto-grants-1978_04
Patent number
US04084049

Reaction notes

Loading…