Ammonium Chloride → HCID 178524458, compound

Participants

Reaction Steps

A mixture of 14.5 g of 2-(4-cyanophenoxy)nicotinic acid, 3.97 g of ammonium chloride, 4.96 g of sodium azide and 120 ml of dimethylformamide is allowed to stand at 100° C to 110° C for 24 hours. After cooling, the reaction mixture is filtered, and the filtrate is concentrated. To the residue is added a dilute hydrochloric acid, and the crystals are filtered off and recrystallized from methanol to give 5 g of 2-[4-(5-1H-tetrazolyl)phenoxy]-nicotinic acid melting at 225° C to 230° C with decomposition.

Provenance & Evidence