Ammonium Chloride → HCID 178479868, compound

Participants

Reaction Steps

A mixture of 5 g of 10-methyl-5-oxo-5H,10H-benzo[b][1,8]naphthyridine-7-carbonitrile, 50 ml of dimethylformamide, 1.45 g of ammonium chloride and 1.8 g of sodium azide is heated with stirring at 110° C to 120° C for 20 hours. After cooling, crystals are filtered off and added to a dilute hydrochloric acid, and the mixture is stirred. The crystals are filtered off, washed with water and recrystallized from dimethylformamide to give 4.3 g of 10-methyl-7-(5-1H-tetrazolyl)-5-oxo-5H,10H-benzo[b][1,8]naphthyridine melting at 321° C with decomposition.

Provenance & Evidence