Hydrochloric Acid → HCID 20358241, compound

Participants

Reaction Steps

A mixture of 3.13 g (0.010 mole) of 4-[5-(3,4-dichlorophenyl)-2-furanyl]-4-oxobutanoic acid and 50 ml of 95% dioxane/water was treated portionwise with 0.95 g (0.025 mole) of NaBH4 while maintaining the temperature below 20° by means of an ice bath. The resulting near solution was allowed to stand overnight at room temperature and was then added to ice/water. After acidifying with 20% hydrochloric acid, the resulting oily mixture was extracted with ether and the ethereal extract dried over MgSO4. The ether was removed on a Calab evaporator yielding 3 g (96%) of product as a residual oil.

Provenance & Evidence