HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanic acid → 3,6-Dibutyl-2,5-dimethylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanic acid | HCID 6347 | — |
| Reactant | 2-Heptanone | HCID 8051 | — |
| Reactant | Nitrosyl chloride | HCID 17601 | — |
| Reactant | 3-Hydroxyiminoheptan-2-one | HCID 57349923 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3,6-Dibutyl-2,5-dimethylpyrazine | HCID 601225 | — |
Reaction Steps
e. 2,5-Dimethyl-3,6-dibutyl-pyrazine was prepared by first forming 3-oximino-2-heptanone by reacting 2-heptanone with nitrosyl chloride according to the method of BOUVEAULT, Bull. [3] 31, 1163 (1904). The autocondensation of two moles of the imino-ketone in the presence of zinc and acetic acid [according to the method described in Chimia 11, 310 (1957)] yielded 2,5-dimethyl-3,6-dibutyl-pyrazine which had a b.p. of 18° C./0.002 mm. Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04085109 |
| Source dataset | uspto-grants-1978_04 |
| ORD ID | ord-2788e04172a64143b311b8a1128da599 |
| Source note | uspto-grants-1978_04 |