Butylamine → 1-Propanesulfonic acid, 3-(butylamino)-

HRID 2083265Notes

Reaction equation

HRID 2083265 reaction equation
[CH2:1]1[S:5](=[O:7])(=[O:6])[O:4][CH2:3][CH2:2]1.[CH2:8]([NH2:12])[CH2:9][CH2:10][CH3:11]>CO>[CH2:8]([NH:12][CH2:3][CH2:2][CH2:1][S:5]([OH:4])(=[O:7])=[O:6])[CH2:9][CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 14264Propane sultone

Product 1

HCID 118308911-Propanesulfonic acid, 3-(butylamino)-Yield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Propanesultone (61g; 0.5 mole) was added to a stirred solution of n-butylamine (36.5g; 0.5 mole) in methanol (200 ml) in 10 min. The reaction temperature was kept at 50°-55° by cooling. After stirring 40 min, a white solid began to separate. After stirring overnight filtration yielded 3-butylaminopropylsulfonic acid 94g (96%).

Workup

  1. customwas kept at 50°-55°
  2. temperatureby cooling
  3. customto separate
  4. stirringAfter stirring overnight
  5. filtrationfiltration

Sources & evidence

ORD record
ord-10b726962d0d461ca56acac7c4623b7c
Source dataset
uspto-grants-1978_04
Patent number
US04085134

Reaction notes

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